Staff Research Associate
Job Description
This position requires a motivated, organized person who can communicate and coordinate well with others, has an interest in learning molecular biology and cutting-edge systems biology approaches, and is eager to engage with research on hepatic stellate cell biology and the mechanisms underlying hepatic fibrosis. The applicant will need previous academic laboratory experience, but training on specific assays and equipment will be provided. The applicant will need to be comfortable with research on experimental mice. The employee will split time ~25/75 between lab management and experimental assistance. Assistance with experiments will be coordinated and in collaboration with the principal investigator and/or experienced lab members, with opportunities to develop the applicant’s own individual project.
The Chen Lab works at the intersection of multiple disciplines to study tissue fibrosis, with a focus on liver fibrosis. Activation of hepatic stellate cells (HSCs) is a central event in liver fibrogenesis, and our lab aims to identify novel mechanisms to inactivate HSCs as a therapeutic strategy. We have discovered exciting molecular targets and validated their roles using conditional knockout mice in multiple models of liver fibrosis, including models that recapitulate nonalcoholic steatohepatitis (NASH). Our lab has also demonstrated that HSCs play a critical role in collagen degradation.
A major focus of our lab is the development of new antifibrotic therapies, as no FDA-approved drugs currently exist that target fibrosis. In parallel, we have developed gene signature scores to identify patients with advanced fibrosis who may benefit from the therapies we are developing.
Our research combines mechanistic studies, translational models, and patient-oriented approaches to advance understanding and treatment of this disease. The Chen Lab is fueled by curiosity, collaboration, and a commitment to progressing the field of liver research.
DUTIES & ESSENTIAL JOB FUNCTIONS
Identify the functions or tasks that employees in the job perform. The essential functions should state the purpose of the work and the results to be accomplished, rather than how the function is performed. Of the tasks listed, what percentage of time is devoted to each? The more time employees spend on a function, the more likely it is that the function is essential. Generally, include those functions that account for 10% or more of the work, i.e., key items that contribute significantly to the achievement of the job. The functions should add up to 100%.
% of time | Essential Function (Yes/No) |
Key Responsibilities (To be completed by Supervisor) |
75 | Yes | Assist with ongoing projects in collaboration with and coordination by experienced lab members in cellular and molecular immunological analyses of genetically engineered mice. Cell preparatory techniques, tissue culture, flow cytometry, RNA preparation, CRISPR based genetic engineering, computational bioinformatic assays, and a variety of molecular assays will be utilized. |
25 | Yes | The incumbent will assist with general operational functions for the laboratory, including maintenance of lab stocks and supplies, and equipment maintenance. The incumbent will be trained as needed to help with other general lab duties. |
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100% | (To update total %, enter the amount of time in whole numbers (without the % symbol - e.g., 15, 20) then highlight the total sum (e.g., 1%) at the bottom of the column and press F9. The total sum should add up to 100%.) |
Required Qualifications
- SRA I: BA/BS in a related science and knowledge of, or experience with, the basic techniques or methods required by the position; or an equivalent combination of education and experience.
- SRA II: In addition to the above, one or more years of recent, directly related work experience following degree completion, utilizing the techniques or methods required by the position; or an equivalent combination of education and experience.
- Basic related scientific techniques and procedures as learned from academic laboratory experience.
- Excellent organizational and interpersonal skills required.
- Ability to use discretion and maintain confidentiality.
Ability to use sound judgement in responding to issues and concerns.
Preferred Qualifications
- Experience with molecular biology techniques, including DNA and/or RNA extraction, PCR, and quantitative PCR (qPCR)
- Experience working with mouse models
- Ability to identify and troubleshoot irregularities or invalid experimental results
- Experience evaluating laboratory procedures and recommending improvements or alternative approaches
- Ability to troubleshoot equipment and resource issues and coordinate necessary repairs
- Experience managing laboratory inventory and sourcing alternative supplies when items are backordered or discontinued
- Experience executing laboratory research projects in collaboration with senior lab members
- Ability to collaborate with postdoctoral fellows and senior lab members to investigate complex experimental issues
- Experience implementing new laboratory techniques based on literature review and consultation with senior team members