Postdoctoral Researcher - Biophysics
Job Description
Summary
The Wang Lab in the Department of Biophysics at the Medical College of Wisconsin is seeking a highly motivated Postdoctoral Fellow to join our research team focused on the structural and functional analysis of oncogenic noncoding RNAs. We utilize a multidisciplinary approach that integrates biochemical, biophysical, and structural biology techniques, including NMR spectroscopy, X-ray crystallography, and cryo-electron microscopy, to explore ribonucleoprotein (RNP) structure–function relationships and identify opportunities for RNP-targeted therapeutic intervention in cancer and related diseases. This position offers an exciting opportunity for candidates passionate about cutting-edge structural biology and RNA-targeted drug discovery, with the potential to develop novel experimental approaches and lead research projects in a collaborative and well-resourced environment.
The Department of Biophysics at the Medical College of Wisconsin has a rich tradition of innovation and excellence in structural biology and biomedical imaging, with particular strengths in EPR (electron paramagnetic resonance), NMR (nuclear magnetic resonance), and MRI (magnetic resonance imaging). The department offers access to state-of-the-art facilities for NMR (solution and solid-state), EPR, MRI, X-ray crystallography, cryo-EM, mass spectrometry, high-performance computing, and biomolecular analysis. MCW is Wisconsin’s largest private research institution and the third-largest private medical school in the U.S. The institution fosters a collaborative environment that integrates basic science, clinical research, and education to advance biomedical knowledge and human health.
Primary Responsibilities
Design and execute experiments to investigate the structure and dynamics of noncoding RNAs and associated RNP using biophysical and structural techniques (e.g., NMR, X-ray crystallography, cryo-EM)
Conduct biochemical assays to study RNA–protein and RNA–small molecule interactions
Perform in vitro transcription, RNA purification, labeling, and structural probing
Analyze experimental data, interpret results, and contribute to manuscript preparation
Present research findings at lab meetings, institutional seminars, and scientific conferences
Mentor graduate students and contribute to training and scientific development within the lab
Assist with the development of grant proposals and collaborative research initiatives
Other duties as assigned.
Knowledge – Skills – Abilities
Hands-on experience in at least one structural biology technique (e.g., NMR spectroscopy, X-ray crystallography, cryo-EM)
Strong background in protein or nucleic acid biochemistry
Proven ability to work independently, manage time effectively, and troubleshoot experiments
Excellent written and verbal communication skills
Exposure to biophysical characterization approaches (e.g., ITC, SPR, and AFM)
Strong publication record in peer-reviewed journals
Familiarity with protein or RNA structural determination
Qualifications
Minimum Required Education: Ph.D. in Biochemistry, Biophysics, Structural Biology, Chemistry, Molecular Biology, or a related discipline (or expected within 6 months of the start date)
Minimum Required Experience: 0 years
Preferred Experience: Experience with protein or RNA expression and purification and in insect and mammalian expression systems
Physical Requirements
Work requires occasionally lifting moderate weight materials, standing, or walking continuously.
Work Environment
Occasional exposure to dust, noise, temperature changes, or contact with water or other liquids. Work is performed in an environmentally controlled environment.
Sensory Acuity
Ability to detect and translate speech or other communication required. May occasionally require the ability to distinguish colors and perceive relative distances between objects.
Why MCW?
Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental. Along with Flexible Spending options
403B Retirement Package
Competitive Vacation and Paid Holidays offered
Tuition Reimbursement
Paid Parental Leave
Employee & Family Assistance Program (EFAP)
Pet Insurance
On campus Fitness Facility, offering onsite classes
Additional discounted rates on items such as: Select cell phone plans, local fitness facilities, Milwaukee recreation and entertainment etc.
For a brief overview of our benefits see: Benefits Overview
For a full list of positions see: MCW Careers
At MCW all of our endeavors, from our internal operations to our interactions with our partners, are driven by our shared organizational values: Caring – Collaborative – Curiosity – Inclusive – Integrity – Respect. We are committed to fostering an inclusive environment that values diversity in backgrounds, experiences, and perspectives through merit-based processes and in alignment with all applicable laws. We believe that embracing human differences is critical to realize our vision of a healthier world, and we recognize that a healthy and thriving community starts from within. Our values define who we are, what we stand for and how we conduct ourselves at MCW. If you believe in embracing individuality and working together according to these principles to improve health for all, then MCW is the place for you. For more information, please visit our institutional website.
MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination:
The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering an inclusive community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.