Principal Scientist and Research Associate - Organic/Peptide/Scaleup/Antibody Drug Conjugation (ADC)

Principal Scientist:

• Lead and manage a multidisciplinary scientific team of 12-15 FTEs ensuring high-quality project delivery.

• Handle client communications and independently manage technical calls with global stakeholders.

• Oversee project planning, execution, timelines, and resource allocation.

• Provide scientific guidance, troubleshooting, and mentoring to team members.

• Ensure compliance with quality, safety, and organizational standards.

• Collaborate cross-functionally to support business and operational goals.

Organic Chemist:

• Hands-on experience in performing chemical reactions from mg to gram scale independently under scientific guidance

• Strong knowledge of analytical and purification techniques, including NMR, Mass, HPLC, CombiFlash, and column chromatography

• Skilled in handling reaction setups, glassware assemblies, reagent charging, temperature control, and nitrogen operations

• Excellent documentation and data management practices with the ability to follow scientific procedures, patents, and experimental instructions accurately
  

Peptide Chemist:

• Hands-on expertise in solid-phase and solution-phase peptide synthesis using automated synthesisers like Syro and Liberty CEM

• Strong experience in peptide purification, characterisation, and analytical techniques, including HPLC, LCMS, and MS

• Capable of independently handling medium- to large-scale peptide synthesis (1 g to 1 kg scale) with troubleshooting abilities

• Skilled in laboratory operations, equipment maintenance, SHE compliance, literature review, and accurate experimental documentation

Scaleup Chemist:

• Experience in process R&D, scale-up synthesis, and purification from gm to kg scale

• Skilled in handling 50L/100L GLR assemblies and basic technology transfer activities

• Proficient in 1H NMR, HPLC, and LCMS interpretation

• Strong project execution and team collaboration skills

Antibody Drug Conjugation Chemist (ADC)

• Synthesis and purification of complex antibody drug conjugate (ADC) molecules

• Synthesis of different types of linkers – using natural and unnatural amino acids, PEGs

• Synthesis of highly potent drug molecules – payloads

• Purification of complex and large molecules by flash column and HPLC

• Handling various type chemistry with different payloads

• Interpretation and characterisation of higher molecular weight compounds