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Scientist - Antibody function and mammalian synthetic biology
Cambridge (USA)Posted 2 months ago
Full-timeonsite
Job Description
The Role
Fueled by partnerships and increasing demand for internal R&D, we will be looking to you to develop and perform high-throughput and multiplex cell-based assays for evaluating antibody function. This will include:
- Engineering transient and stable cell lines with diverse reporters in both model and disease systems
- Collecting and analyzing quantitative measurements using flow cytometry, immunoassays, -omics (pooled, single cell), and other techniques.
- Prioritizing top development candidates by functional and binding characterization
- Working together with our dry-lab and other wet-lab scientists to establish a rapid and seamless testing pipeline for characterizing machine learning generated antibody designs
Qualifications
- PhD-level knowledge and experience in mammalian synthetic biology and cellular assay development
- Extensive experience in molecular biology: plasmid design, single-insert cloning, library cloning, bacterial transformation and culturing.
- Extensive experience in cell line engineering and tissue culture. Includes experience with transient and stable transfections, lentiviral transduction, electroporation; and, experience troubleshooting biological readouts. Experience culturing a wide variety of immortalized and primary disease cells is a plus.
- Well-organized, and would enjoy establishing an operationally efficient engineering and characterization pipeline that works reliably
- Problem-focused, and interested in working in a high-intensity, fast-paced environment often driven by deadlines
- Value unblocking colleagues before yourself, and are excited to mentor/train junior colleagues
What We Offer
- A fast-moving environment where you can build and ship tools that impact real drug programs
- A small, focused team where your scientific and engineering decisions have outsized impact
- Highly competitive salary, equity, and benefits package