Associate Scientist

• A position is available for a skilled bioanalytical scientist to join a state-of-the-art mass spectrometry laboratory in PDM with deep expertise in bioanalytical quantitation

• The lab based role entails the development of ultra-sensitive quantitative assays for small and large molecule biomarkers in relevant cells and biological fluids (plasma, tissue, etc.)

• This position requires strong bioanalytical expertise, proven expertise in chromatography, triple quadrupole quantitative mass spectrometry and potentially HRMS

• The candidate will participate in all phases of mass spec laboratory operations including the development of sample preparation and separation methods, assay execution, instrument maintenance, data analysis and reporting

• Run bioanalytical assays under minimal supervision; initiative in method development is expected

• Independent daily operation, calibration, maintenance, and trouble-shooting of multi-dimensional chromatography and triple quadrupole mass spectrometry instrumentation (high flow to nano scale, HPLC and SFC)

• Support analysis of lipid panel using SFC-MS/MS 

• Support analysis of quantitative LC-MS/MS data using relevant bioinformatics and quantitation software

• Apply existing protein quantitation workflows using bead and column based immunoaffinity enrichment including the use of automation

• Support bio-marker and PK/PD studies as needed

• BS/MS level education in chemistry, biochemistry or related fields required; advanced degree may be a plus

• Industry experience in biopharma preferred

• Expertise in the operation and maintenance of LCs and mass spectrometers

• Experience with basic and complex quantitative LC-MS/MS assays (both large and small molecule LC/MS). Track record of method development skills particularly with novel and complex methods applied to bioanalytical questions

• Work well both independently and as part of a team. Collaborative skills and effective partnering skills in a matrix-environment

• Strong data organization and analysis skills and passion to learn new things in a fast paced environment

• Strong communication skills

• Experience with super critical fluid chromatography, immunoaffinity enrichment techniques or nano scale chromatography is a plus

• Strong excel based skills is also a plus

• Experience with Watson is a plus

Thanks

Regards

Ricky