Director, IT Enterprise Delivery and Portfolio

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Director, IT Enterprise Delivery & Portfolio will lead Madrigal IT’s end-to-end delivery discipline across the project portfolio, ensuring we have a single, trusted view of what is happening, what is at risk, and what decisions are needed. This role will own the portfolio operating rhythm and governance mechanisms that bring structure to demand intake, prioritization, sequencing, dependency management, and escalation—so leaders can make timely, informed tradeoffs and avoid surprises.

Reporting to the Sr. Director, IT Strategy & Operations, this leader will help operationalize “how we run IT” by strengthening execution quality, predictability, and accountability across programs and projects, while keeping the organization focused on the highest-value work. The goal is to accelerate delivery of strategic outcomes by improving transparency, standardizing ways of working, and proactively removing barriers—so IT can scale with the business without increasing noise, risk, or decision latency.

Key Responsibilities

• Portfolio Leadership
  • Accountable for the end-to-end intake, prioritization, and sequencing process for the IT portfolio, ensuring timely, high-quality decisions.
  • Run portfolio governance forums and drive decision discipline, escalation, and follow-through
  • Maintain portfolio health visibility across milestones, risks, dependencies, and outcomes
  • Drive on-time, on-budget delivery across multiple concurrent initiatives
  • Define, track and continuously improve portfolio-level KPIs
• Delivery & Execution Discipline
  • Establish consistent delivery standards for planning, RAID, change control, and status integrity
  • Drive cross-functional dependency management and unblock delivery across domains and vendors
  • Enforce delivery discipline across the portfolio
  • Improve predictability through stage-appropriate checkpoints and executive-ready reporting
  • Capture lessons learned and continuously strengthen “how Madrigal delivers”
• Strategic Planning & Roadmapping
  • Partner with IT and business leaders to ensure delivery plans reflect enterprise commitments
  • Build a single, executive-ready narrative that connects delivery progress, risk, and capacity to enterprise priorities and outcomes
  • Support quarterly recalibration based on performance, capacity, and shifting priorities
• Delivery Constraints & Capacity Management
  • Maintain a forward-looking view of delivery capacity and constraints across teams and partners (skills, bandwidth, vendor throughput).
  • Surface delivery restraints early (dependencies, environment readiness, data/integration gaps, compliance gates, funding timing) with clear options and tradeoffs.
  • Drive timely escalation and decision-making to protect critical milestones; recommend re-sequencing, de-scoping, or resourcing actions as needed.
  • Reduce chronic overload by enforcing prioritization discipline and minimizing fragmented, low-value work.
• Delivery Leadership
  • Lead and develop a team of project/program managers; set expectations, coach execution quality, and ensure consistent standards.
  • Directly manage select high-priority initiatives as the project/program manager (hands-on ownership from plan through delivery).
  • Create a strong PM community of practice (templates, tooling, training, lessons learned) that raises delivery maturity over time.
  • Ensure contractors and external PM resources operate within Madrigal’s governance, reporting, and delivery norms.

• Other duties as assigned

Required & Desired Qualifications

• Bachelor’s degree in Information Systems, Computer Science, Engineering, Business, or related field.
• Advanced degree (MBA or related) preferred.
• 12+ years of relevant IT experience across a broad technology landscape including applications, PMO, data, and AI.
• Experience in biotech/pharma or other regulated industries strongly preferred.
• Track record leading cross-functional portfolios, improving SLAs/OLAs, and maturing ITIL processes.
• Hands-on experience with IT financial management, vendor/SOW oversight, and contract negotiations.
• Proven ability to prepare executive materials and drive decisions with data and clear tradeoffs.

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands.  As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $202,000 - $247,000 per year.  We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].