Bioinformatician - Genomics at NHG Health

Bioinformatician (Genomics)

Responsibilities

Lead the design, development, validation, and upkeep of bioinformatics pipelines supporting clinical genomic testing services
Conduct end-to-end genomic and multi-omics data analysis (NGS, WES/WGS, ctDNA, PGx, MRD, PRS), including interpretation for clinical reporting
Build, optimise and maintain robust, scalable, and reproducible workflows, tools, and databases for high-throughput operations
Develop pipelines using Python, R, Bash, Linux, and workflow engines (Nextflow/Snakemake), including custom tool development
Collaborate with clinicians and multidisciplinary teams to deliver accurate, clinically actionable insights and reports
Integrate diverse data sources (clinical, internal, public) for variant classification and evidence-based recommendations
Deploy and manage pipelines on local/cloud/HPC infrastructure, ensuring performance, security, and compliance
Drive adoption of emerging technologies (AI/ML, long-read sequencing, advanced analytics) and support validation efforts
Ensure adherence to regulatory, quality, and data governance standards (e.g. CAP, HCSA, PDPA), including audits and documentation
Provide scientific leadership, mentorship, and research contributions, including publications, grants, and innovation initiatives

Requirement

PhD (or equivalent experience) in Bioinformatics, Computational Biology, Molecular Biology, or related field
4-8 years experience in clinical/translational genomics with pipeline development and next generation sequencing analysis
Strong programming skills (Python, R, Bash, C/C++) and experience building reproducible workflows (Nextflow/Snakemake/WDL/CWL)
Hands-on expertise in NGS data analysis (alignment, variant calling, CNV/SV detection, annotation) and genomic databases
Proficiency in Linux/Unix, Git, and experience with HPC or cloud computing environments
Track record in publications, presentations, or assay/method development is advantageous
Solid understanding of statistics, data science, and quality control in genomic assays
Excellent problem-solving, organisation, and attention to detail, with focus on scalability and reproducibility
Strong communication and collaboration skills, able to work with clinicians, scientists, and IT teams

Bioinformatician - Genomics