Senior Research Associate & Group Leader - DMPK

Senior Research Associate - DMPK

• Perform routine in vitro ADME assays such as microsomal stability, plasma stability, solubility, permeability, CYP inhibition, and plasma protein binding assays

• Develop, optimise, and execute analytical methods using LC-MS/MS and complementary detection modalities (absorbance/fluorescence-based assays)

• Support development and validation of new ADME assays to expand the group’s scientific capabilities

• Process and analyse experimental data using GraphPad Prism, MS Excel, and mass spectrometry software platforms (e.g., Sciex)

• Prepare clear experimental documentation, study summaries, and reports for internal teams and external collaborators

• Coordinate with third-party collaborators for pharmacokinetic (PK) studies, including in vivo animal studies where applicable

• Present experimental results and scientific observations in internal meetings, project reviews, and cross-functional discussions

• Work closely with colleagues across biology, and ADME groups to provide integrated drug discovery support alongside chemistry teams

• Support laboratory operations including reagent ordering, inventory management, assay consumables tracking, and coordination of laboratory logistics

Group Leader - DMPK

• Lead, mentor, and develop a team of scientists engaged in In-Vitro ADME/DMPK studies.

• Oversee the design, execution, analysis, and interpretation of In-Vitro ADME studies, including metabolism, transporter, and drug-drug interaction assessments.

• Manage external CRO partnerships for In-Vivo PK studies, ensuring timely execution, data quality, and delivery.

• Provide scientific guidance and DMPK strategies to support drug discovery and development projects.

• Analyze and interpret study data, prepare technical reports, and present findings to internal and external stakeholders.

• Serve as the primary scientific point of contact for clients, ensuring effective communication and project delivery.

• Support proposal preparation, project scoping, contract review, and project onboarding activities.

• Manage study budgets, resource allocation, and operational efficiency.

• Drive continuous improvement initiatives and implement best practices across DMPK operations.

• Collaborate closely with cross-functional teams to integrate ADME/DMPK data into project decisions.

• Prepare and present monthly MIS reports, including project status, resource utilization, risks, and key performance metrics.