Post-Doctoral Associate
Job Description
Post-Doctoral Associate
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The laboratory of Dr. Maciej Walczak at the University of Colorado Boulder is seeking a highly motivated Postdoctoral Associate to join an interdisciplinary research program at the interface of chemical biology, biophysics, and neurodegeneration. Our research is focused on uncovering how site-specific glycosylation rewires the structure and function of hallmark proteins in AD. This project combines chemical synthesis with advanced biophysical and cellular approaches to define how PTMs regulate protein conformation, receptor interactions, aggregation, clearance, and spread. The successful candidate will work closely with a multidisciplinary team to perform quantitative biophysical assays alongside complementary cellular studies in human iPSC-derived models. The position emphasizes developing a mechanistic, structure–function understanding of protein functions. The candidate will also contribute to data integration across chemical, biophysical, and cellular platforms and assist with mentoring junior researchers and maintaining an organized, collaborative lab environment. This is an excellent opportunity for a candidate interested in linking molecular precision to human disease biology, and in gaining experience in a highly collaborative and fast-paced research environment spanning chemical biology, biophysics, and neurodegeneration.
The Department of Chemistry at the University of Colorado Boulder is proud to be a vibrant, research-driven department dedicated to exploring the fundamental nature of matter and energy. Our faculty, students, and staff are engaged in groundbreaking work across a wide range of fields—from analytical, organic, and physical chemistry to materials and nanoscience. Nationally recognized and consistently ranked among the top programs in the country, our department is home to award-winning researchers, innovative educators, and a collaborative spirit that drives discovery. To learn more about our department and our team please visit our website: https://www.colorado.edu/chemistry/
- Design and execute biophysical experiments.
- Measure binding kinetics and affinities.
- Map conformational dynamics and structural changes associated with glycosylation and ligand binding.
- Analyze and interpret complex datasets, including kinetic modeling and structure–function relationships.
- Mentor graduate students and undergraduate researchers in experimental design and data analysis.
- Prepare manuscripts, figures, and grant contributions in collaboration with the PI and team members.
- Present research findings at group meetings, departmental seminars, and national/international conferences.
- This position is 100% in person and does not require any travel or work outside of normal business hours.
- The anticipated start date for this position is June 2nd, 2026.
The annual salary range for this full-time position is $60,000-70,000.
At the University of Colorado Boulder, we are committed to supporting the holistic health and well-being of our employees. Our comprehensive benefits package includes medical, dental, and retirement plans; generous paid time off; tuition assistance for you and your dependents; and an ECO Pass for local transit. As one of Boulder County’s largest employers, CU Boulder offers an inspiring academic community and access to world-class outdoor recreation. Explore additional perks and programs through the CU Advantage program.
- Ph.D. in Biochemistry, Biophysics, Chemical Biology, or related field.
- Strong background in protein biophysics and/or biophysical methods development.
- Interest in neurodegeneration and interdisciplinary research.
- Excellent written and oral communication skills.
- Strong analytical and interpersonal problem-solving skills.
- Excellent organizational skills.
- Experience with BLI/SPR or other kinetic binding platforms, protein aggregation assays, mass spectrometry or structural methods.
- Familiarity with modern imaging techniques.
- Experience with protein chemistry techniques.
To apply, please submit the following materials as PDF documents:
- Resume/CV.
- Cover Letter.
- One Reference Letter (Non-Confidential).
- Optional: If you are selected as the finalist, your degree will be verified by the CU Boulder Campus Human Resources department using an approved online vendor. If your degree was obtained outside of the United States, please submit a translated version as an optional attachment.
Please apply by May 5th, 2026 for consideration.
Note: Application materials will not be accepted via email. For consideration, applications must be submitted through CU Boulder Jobs.
Posting Contact Information
Posting Contact Name: Boulder Campus Human Resources
Posting Contact Email: [email protected]