Back to jobs
Alnylam Pharmaceuticals

Senior Director, Biocatalysis

Cambridge, MAPosted 6 days ago

Job Description

  • Develop and lead the biocatalysis strategy across starting materials, oligonucleotides, and small molecule processes.
  • Identify high-impact opportunities for biocatalyst substitution, new enzymatic chemistry, and improved synthetic routes.
  • Lead enzyme discovery, engineering, screening, and optimization through internal capabilities and external partnerships.
  • Establish internal protein screening and engineering capabilities, including protein design, expression, purification, characterization, and reaction screening.
  • Drive biocatalytic applications for oligonucleotide synthesis and small molecule process development.
  • Partner with Process Chemistry, CMC, Manufacturing, Quality, and Regulatory teams to translate biocatalytic concepts into scalable, robust, and manufacturable processes.
  • Manage strategic collaborations with academic institutions, CROs/CDMOs, and enzyme discovery or engineering companies.
  • Evaluate emerging technologies and external opportunities in biocatalysis, protein engineering, and biocatalyst manufacturing.
  • Serve as the technical authority for biocatalysis, providing scientific guidance, risk assessments, and recommendations to senior stakeholders.
  • See Your Match Score

    Sign up and Renata will show you how this job matches your skills and experience.

    1001-5000 employees
    Cambridge, Massachusetts, US
    Website
    Senior Director, Biocatalysis at Alnylam Pharmaceuticals | Renata