Post Doctoral Scholar - Comprehensive Cancer Center

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Job Title:

Post Doctoral Scholar - Comprehensive Cancer Center

Department:

Medicine | Surgical Oncology

Postdoctoral Scholar – Thege Laboratory, Division of Surgical Oncology
 

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC–James) is a nationally recognized, NCI-designated comprehensive cancer center integrated within one of the nation’s largest public research universities. The OSUCCC–James brings together world-class researchers and clinicians to accelerate discoveries and translate them into improved cancer prevention, detection, and treatment.

The Thege Laboratory, within the Division of Surgical Oncology, is seeking a highly motivated and creative Postdoctoral Scholar to join our team. Our research is focused on developing rational drug combinations for KRAS-mutant pancreatic and lung cancers, with an emphasis on identifying therapeutic vulnerabilities and overcoming resistance mechanisms.

Research Focus

The successful candidate will contribute to innovative, translational research using a combination of cutting-edge experimental systems and technologies, including:

• Human surgical specimens and translational tissue-based studies
• Patient-derived organoid (PDO) models
• Autochthonous genetically engineered mouse models (GEMMs)
• In vitro and ex vivo drug screening platforms
• In vivo CRISPR activation (CRISPRa) screening approaches
• Multi-omic profiling, including:
  • Single-cell RNA sequencing (scRNA-seq)
  • Spatial transcriptomics
  • Bulk RNA sequencing

Our goal is to integrate functional screening with high-dimensional molecular profiling to uncover actionable therapeutic strategies for aggressive KRAS-driven malignancies.

Key Responsibilities

• Design, execute, and interpret independent and collaborative research projects aligned with lab goals
• Perform in vitro and in vivo experiments, including drug screening and mouse studies
• Develop and optimize organoid and tumor models
• Conduct and/or analyze high-throughput sequencing datasets (scRNA-seq, spatial transcriptomics, bulk RNA-seq)
• Maintain detailed experimental records and ensure rigorous reproducibility
• Prepare manuscripts and contribute to grant applications
• Present findings at lab meetings, institutional seminars, and national/international conferences
• Collaborate effectively with multidisciplinary teams across the OSUCCC
   

Minimum Qualifications

• PhD in Cancer Biology, Molecular Biology, Biomedical Sciences, or a related field
• Strong background in molecular and cellular biology techniques, including cell culture, nucleic acid handling, and protein analysis
• Demonstrated experience with animal models (mouse experiments required)
• Hands-on expertise in wet lab research, with the ability to work independently
   

Preferred Qualifications

• Experience with organoid culture systems or primary patient-derived samples
• Familiarity with functional genomics approaches, including CRISPR-based screening
• Experience analyzing or interpreting omics datasets (RNA-seq, single-cell, or spatial data)
• Basic proficiency in coding or bioinformatics (e.g., R, Python) is strongly preferred
• Prior experience working in cancer biology, particularly in pancreatic, lung, or KRAS-driven cancers, is a plus.
   

Candidate Profile

We are seeking an individual who is:

• Highly motivated, organized, and intellectually curious
• Comfortable working both independently and as part of a collaborative, interdisciplinary team
• Committed to rigorous science and translational impact

Additional Information:

Location:

Biomedical Research Tower (0112)

Position Type:

Term (Fixed Term)

Scheduled Hours:

40

Shift:

First Shift

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