Postdoctoral Researcher in Metabolic Disease and Cell Signalling
Job Description
Full time, fixed term until 31st December 2028, located on the Camperdown Campus at the School of Life and Environmental Sciences (SOLES)
Opportunity to make valuable contributions to research in Metabolic disease
Base Salary, level A $105,314 - $116,679 p.a + 17% superannuation
About the opportunity
The School of Life and Environmental Sciences (SOLES) is currently seeking a Postdoctoral Researcher in Metabolic Disease and Cell Signalling to carry out independent research, keeping with the aims of the laboratory and the Charles Perkins Centre (CPC).
The successful candidate will contribute to projects focused on understanding the molecular and cellular mechanisms underlying metabolic disease, with a particular emphasis on protein trafficking, signalling pathways, membrane transport, proteomics, and systems-level regulation of metabolism.
The role will involve the integration of biochemical, molecular, cellular, and in vivo approaches to investigate disease mechanisms and identify novel therapeutic targets.
Your key responsibilities will be to:
participate in and drive laboratory research programs focused on metabolism and cell signalling
carry out independent research aligned with the strategic aims of the laboratory and the CPC
coordinate and manage multiple research projects to ensure timely completion of milestones and publications
develop, optimise, and apply advanced methodologies in protein biochemistry, molecular biology, proteomics, and cell biology
perform mechanistic studies in mammalian cell systems and mouse models
design and implement CRISPR/Cas9-based genetic manipulation approaches in cells and animal models
conduct biochemical and enzymatic assays to investigate protein function, signalling pathways, and metabolic regulation
undertake proteomic and mass spectrometry-based analyses of proteins and signalling networks
contribute to screening approaches, including functional and biochemical screening strategies
supervise honours, PhD, and postgraduate students and provide mentorship in experimental design and data analysis
foster collaborations within the laboratory, CPC, and broader national and international research community
present research findings at national and international scientific meetings and publish in high-impact peer-reviewed journal
contribute to grant applications and help secure national and international competitive funding
disseminate technical expertise and train other laboratory members in specialised methodologies.
About you
The University values courage and creativity; openness and engagement; inclusion and diversity; and respect and integrity. In addition, we are seeking a highly motivated Postdoctoral Researcher with some of the following skills:
a PhD (or near completion) in biochemistry, molecular biology, cell biology, metabolism, or related discipline
strong expertise in protein biochemistry and molecular mechanisms of cell signalling
experience in mammalian cell culture and molecular cloning techniques
expertise in CRISPR/Cas9-mediated genome engineering
experience with proteomics and mass spectrometry-based approaches
experience performing enzyme assays and mechanistic biochemical studies
expertise in molecular biology techniques including plasmid design, mutagenesis, and gene expression analysis
experience working with mouse models and small animal experimentation would be an advantage.
experience in functional screening approaches and/or assay development
expertise in fluorescence microscopy and imaging approaches
strong analytical and problem-solving skills, including experience analysing complex biological datasets
the ability and willingness to work collaboratively within multidisciplinary research teams
excellent written and verbal communication skills
a strong publication track record relative to career stage
experience with quantitative proteomics and/or phosphoproteomics would be an advantage.
Pre-employment checks
Your employment is conditional upon the completion of all role required pre-employment or background checks in terms satisfactory to the University. Similarly, your ongoing employment is conditional upon the satisfactory maintenance of all relevant clearances and background check requirements. If you do not meet these conditions, the University may take any necessary step, including the termination of your employment.
EEO statement
At the University of Sydney, our shared values include diversity and inclusion and we strive to be a place where everyone can thrive. We are committed to creating a University community which reflects the wider community that we serve. We deliver on this commitment through our people and culture programs, as well as key strategies to increase participation and support the careers of Aboriginal and Torres Strait Islander People, women, people living with a disability, people from culturally and linguistically diverse backgrounds, and those who identify as LGBTIQ. We welcome applications from candidates from all backgrounds.
How to apply
Applications (including a cover letter, CV, and any additional supporting documentation) can be submitted via the Apply button at the top of the page.
Candidates should indicate which level they wish to apply for; however, the selection panel reserves the right to make offers based on its appraisal of the candidate’s skills, experience, and knowledge.
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For a confidential discussion about the role, or if you require reasonable adjustment or any documents in alternate formats, please contact Simon Drew, Recruitment Operations, Human Resources at [email protected]
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Applications Close
Sunday 19 July 2026 11:59 PM